![]() ![]() ![]() These proteins were analyzed according to specific criteria to create a focus list that contained 37 proteins. The majority of these proteins (221) were up-regulated in exosomes from prostate cancer patients. Importantly, 246 proteins were differentially expressed in the two groups. In total, 15 control and 16 prostate cancer samples of urinary exosomes were analyzed. We have here investigated the proteome of urinary exosomes by using mass spectrometry to identify proteins differentially expressed in prostate cancer patients compared to healthy male controls. Received: ApAccepted: JPublished: July 13, 2015Įxosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumour-specific molecules can be found in exosomes isolated from biological fluids. Keywords: biomarkers, exosomes, extracellular vesicles, mass spectrometry, prostate cancer Koehler 3,4, Bernd Thiede 3,4, Therese Seierstad 5, Viktor Berge 6, Kirsten Sandvig 1,2,4 and Alicia Llorente 1,2ġ Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, NorwayĢ Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norwayģ The Biotechnology Centre of Oslo, University of Oslo, Oslo, NorwayĤ Department of Biosciences, University of Oslo, Oslo, Norwayĥ Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayĦ Department of Urology, Oslo University Hospital, Oslo, Norway Anders Øverbye 1,2, Tore Skotland 1,2, Christian J. ![]()
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